Mario&Luigi Partners in Time.
It may drive me bonkers (console RPGs often grind me down, and I can't imagine a Mario rpg is going to have much in the way of plot)
edit: CUUUUUUUTE! (Not stylus-based, but it thinks about what's comfortable and instinctive to do with the buttons, and is much less annoying to control than rune factor was. However, it does tire my hands out after a half-hour or so.)