This is partly for my own interest, to scrounge around and see what games out there had a female lead designer - and what kind of games. I don't care who made a game if it's fun, but it's interesting to see, isn't it?
So, first, the obvious links:
Tale of Tales (You may know them from 'The Endless Forest')
Some of you will definitely remember names like Roberta Williams (King's Quest) and Lori Cole (Hero's Quest/Quest for Glory) from the old Sierra days.
In "games specifically intended for girls" there's Brenda Laurel, from Purple Moon (possibly others there as well). And Her Interactive, which makes the Nancy Drew games.
WAY WAY BACK in ancient Atari History, we had Dona Bailey and Carol Shaw (Centipede, 3d Tic Tac Toe, River Raid). Slightly more recent than that, Amy Briggs wrote 'Plundered Hearts' in the text adventure age (was also specifically targeted at women). Digging around, I can also find a Nicky Robinson, who worked on several games but is credited as a major designer/developer on "Mail Order Monsters", which I've never heard of.
In freeware, "Emily Short" (apparently not her real name, perhaps to avoid conflict with the day job?) is considered one of the top figures of modern Interactive Fiction.
I can find a few people who worked as designers on some MMORPGs, notably Shadowbane, but those teams are so huge I don't think that counts. There are many more women who work IN the games industry, but I'm particularly interested in games primarily created/directed by women. Throw me some links, people?